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Wednesday, May 27, 2020

Covid19 and risk of Stroke

The current Covid19 pandemic has dramatically changed the world and the way we live. The various ways in which Covid presents itself in people has not been clearly understood and new mechanisms are being learnt everyday.

One of the ways that Covid19 manifests itself is in the form of 'Stroke'. Acute Stroke in people suffering from Covid19 may present in many ways such as blockage of important arteries of the brain or bleeding within the brain. Blockage of important arteries supplying important arteries of the brain leads to acute loss of blood circulation to important parts of the brain and thus permanent damage to the brain resulting in disability or death. It has been observed that strokes in codiv19 occur predominantly in younger population than old. One of the mechanisms that is proposed to be the cause of stroke is a hyper coagulable state, which means increased tendency of the blood to clot. The exact mechanism of this hypercoagulable state is unknown, This has also led to administration of blood thinners to people affected with covid19 in the hope that the blood remains adequately thin so as to prevent abnormal clotting.

The main stay of treatment of such blockages leading to stroke is blood thinners and a procedure called 'mechanical thrombectomy', which involved extracting the clot from the area of blockage by angiography techniques. The results of treatment are good, although not as good as in non-covid patients.

Due to the widespread of the novel coronavirus, the incidence of new strokes in especially younger population is likely to increase significantly and hence it is imperative to be aware of signs and symptoms of stroke. For more details on how to identify stroke, click on https://www.youtube.com/watch?v=6oGUwNxRbmU&feature=youtu.be

Thursday, April 11, 2019

Awake Craniotomy for Brain Tumor Resection


Awake brain surgery, also called awake craniotomy, is a type of procedure performed on the brain while the person is awake and alert. Most of the brain surgeries involve general anesthesia wherein the patient is completely sedated and paralyzed and his/her breathing is controlled by the ventilator.
Awake brain surgery involves keeping the person awake and alert during surgery so as to be able to monitor his/her brain function while a surgical procedure is being performed on the brain.
Awake brain surgery is used to treat some brain tumors that are in close proximity to important functional areas of the brain such as the speech area and motor area. Patient’s responses help the surgeon to ensure that the functional area under consideration is preserved, thus preserving function. The procedure also lowers the risk of damage to functional areas of your brain that could affect your vision, movement or speech.


Why it's done?
If a tumor or section of your brain that causes seizures needs surgical removal, doctors must be sure that they are not damaging an area of the brain that affects your language, speech and motor skills.
It's difficult to pinpoint those areas exactly before surgery. Awake brain surgery allows the surgeon to know exactly which areas of the brain control those functions and avoid them.

Before surgery

Not all patients are fit candidates for awake craniotomy. The treating neurosurgeon and neuroanesthesiologist examine the patient thoroughly and discuss the steps in surgery. The patient is an active participant in this surgery and his/her responses during surgery will play a pivotal role in preserving brain function. A neuropsychological assessment is performed to assess deficits in higher mental functions and speech prior to the surgery.
Before surgery, the neurosurgeon or a speech-language pathologist may ask the patient to identify pictures and words on cards or on a computer so that the answers can be compared during surgery.

During surgery

Brain mapping

An anesthesia specialist (anesthesiologist) will apply numbing medications to the scalp to ensure your comfort.
During the procedure, doctors place the patient’s head in a fixed position to keep the head still and ensure surgical accuracy. Some of the hair will be clipped. Your surgeon then removes part of the skull to reach the brain.
The patient may be sedated and sleepy while part of the skull is removed in the beginning of the surgery, and also when doctors reattach the skull at the end of the surgery. During the surgery, the anesthesiologist will stop administering the sedative medications and allow the patient to wake up.
If the brain tumor or epileptic focus is close to areas of your brain that control vision, speech or movement, the neurosurgeon will conduct brain mapping. This provides the neurosurgeon with a map of the brain centers that control each of these functions. The surgeon also can perform brain mapping deeper in your brain during surgery.
The anesthesiologist and surgical team carefully monitors and assess your body and brain functions and alerts your surgeon if surgery affects brain function.

After surgery

The patient is observed in the intensive care unit for a while after surgery and spends about three to five days in the hospital.
The patient generally may return to work and normal activities in six weeks to three months.


Tuesday, July 10, 2018

Superficial Temporal Artery Dissection for STA-MCA bypass procedure

The video demonstrates the technique of superficial temporal artery dissection for STA-MCA bypass procedure

Please click here to view the video

Thursday, June 28, 2018

Sylvian Fissure Dissection

The current video demonstrates distal-to-proximal dissection of Sylvian Fissure. Please click on the following link to view the video

Sylvian Fissure Dissection

Tuesday, March 13, 2018

Vestibular Schwannoma




What is a vestibular schwannoma (acoustic neuroma)?

A vestibular schwannoma (also known as acoustic neuroma, acoustic neurinoma, acoustic schwannoma, or acoustic neurilemoma) is a benign, slow-growing tumor that develops from the nerves that control balance and hearing. Approximately one out of every 100,000 individuals per year develops a vestibular schwannoma.
The tumor arises from an overproduction of Schwann cells—the cells that normally wrap around the nerves to help support and insulate nerves and transmit impulses. As the tumor grows, it affects the hearing and balance nerves, usually causing hearing loss on that side, tinnitus (ringing in the ear), and imbalance while walking. As the tumor grows, it can interfere with the sensations over the face (the trigeminal nerve), causing facial numbness. Vestibular schwannomas can also affect the facial nerve (for the muscles of the face) causing facial weakness or paralysis on the side of the tumor. If the tumor becomes large, it will eventually press against nearby brain structures (such as the brainstem and the cerebellum), which could be life-threatening.


How is a vestibular schwannoma diagnosed?

One sided hearing loss and/or tinnitus and loss of balance/dizziness are early signs of a vestibular schwannoma. Unfortunately, early detection of the tumor is sometimes difficult because the symptoms may be subtle and may be ignored in the early stages of growth. Also, these symptoms are commonly encountered in many middle and inner ear problems. Once the symptoms appear, a thorough ear examination and hearing and balance testing (audiogram) are essential for proper diagnosis. Magnetic resonance imaging (MRI) scans are critical in the early detection of a vestibular schwannoma and are helpful in determining the location and size of a tumor and in planning its treatment.


How is a vestibular schwannoma treated?

There are three options for managing a vestibular schwannoma:
(1) surgical removal,
(2) radiation, and
(3) observation.

Sometimes, the tumor is surgically removed (excised). The exact type of operation done depends on the size of the tumor and the level of hearing in the affected ear. If the tumor is small, hearing may be saved and accompanying symptoms may improve by removing it to prevent its eventual effect on the hearing nerve. As the tumor grows larger, surgical removal is more complicated because the tumor may have damaged the nerves that control facial movement, hearing, and balance and may also have affected other nerves and structures of the brain.

The removal of tumors affecting the hearing, balance, or facial nerves can sometimes make the patient’s symptoms worse because these nerves may be injured during tumor removal.

As an alternative to conventional surgical techniques, radiosurgery (that is, radiation therapy—the “gamma knife” or LINAC based Stereotactic Radiotherapy) may be used to reduce the size or limit the growth of the tumor. Radiation therapy is sometimes the preferred option for elderly patients, patients in poor medical health, patients with bilateral vestibular schwannoma (tumor affecting both ears), or patients whose tumor is affecting their only hearing ear. When the tumor is small and not growing, it may be reasonable to “observe” the tumor for growth with periodic MRI scans.
Bilateral vestibular schwannomas affect both hearing nerves and are usually associated with a genetic disorder called neurofibromatosis type 2 (NF2). Half of affected individuals have inherited the disorder from an affected parent and half seem to have a mutation for the first time in their family. Each child of an affected parent has a 50 percent chance of inheriting the disorder. Unlike those with a unilateral vestibular schwannoma, individuals with NF2 usually develop symptoms in their teens or early adulthood. In addition, patients with NF2 usually develop multiple brain and spinal cord related tumors. They also can develop tumors of other nerves in the brain or elsewhere in the body.


What is the outcome of patients treated for vestibular schwannoma?

Most patients with vestibular schwannoma that undergo treatment (surgery or radiosurgery) go on to lead a normal healthy life with or without some morbidity pertaining to facial nerve function. The outcome following successful vestibular schwannoma surgery is extremely good.

Tuesday, May 9, 2017

Hydrocephalus

What is Hydrocephalus?

Hydrocephalus is the abnormal accumulation of fluid (Cerebrospinal fluid) within the cavities (ventricles) of the brain. Cerebrospinal fluid or CSF is normally produced in the ventricles and absorbed such that there is almost a constant volume of the fluid in a normal person.

When there is an imbalance between the production and absorption of the CSF, it results in Hydrocephalus

Who is at risk of developing Hydrocephalus?

Hydrocephalus can occur at any age depending on the cause. However, it is most common in infants and older children. The exact incidence in India is not known. In the United States, of 1000 babies born, 1-2 develop Hydrocephalus.

What are the symptoms?

Infants

  1. Unusually large head
  2. Rapid increase in the size of the head
  3. Bulging or tense fontanelle
  4. Vomiting
  5. Poor feeding
  6. Irritability
  7. Eyes fixed downwards
  8. Delayed milestones
Children
  1. Excessive sleepiness
  2. Irritability
  3. Declining school performance
  4. Headache, vomiting
  5. Double vision or blurred vision
  6. Difficulty in concentrating on routine tasks
Adults
  1. Urinary incontinence
  2. Imbalance while walking
  3. Memory loss
How is Hydrocephalus diagnosed?

After a thorough history and physical examination by the attending Neurologist/Neurosurgeon, one of the following tests may be performed to confirm the diagnosis
  1. Ultrasound imaging in newborns and infants
  2. Computed Tomography (CT)
  3. Magnetic Resonance Imaging (MRI)
How is Hydrocephalus treated?

Depending upon the severity and cause of hydrocephalus, your Neurosurgeon may recommend the following 
  1. Ventriculoperitoneal Shunt surgery - This surgery involves inserting a tube in the ventricles of the brain and placing it in the abdomen so that the excess fluid is drained into the abdomen where it is absorbed by the peritoneum
  2. Endoscopic Third Ventriculostomy (ETV) - In this procedure, the neurosurgeon uses a video camera to make a hole in the ventricle so that excess fluid is drained into the subarachnoid space where it is absorbed.
  3. Close observation - In rare cases, when the hydrocephalus is mild and the cause has been treated, one may just closely follow-up the serial imaging. If the cause has been treated, hydrocephalus may resolve on its own

Wednesday, February 22, 2017

Brain tumors in Children

Though rare, brain tumors are the most common form of solid tumors among children under the age of 15 and represent about 20% of all childhood cancers.  Brain tumors in children are often located in different locations and behave differently than brain tumors in adults.  Consequently, management of tumors in children varies from that in adults.  Children with tumors may also have a much better prognosis than adults with a similar condition.

Understanding Tumors
There are different brain tumor types and classifications based upon a tumor’s cell of origin, cell type, composition, rate of growth and other characteristics. 

Most pediatric brain and spine tumors are primary tumors, meaning they originated in the brain or spine.  In contrast, the most common brain tumors in adults are metastases, meaning they represent spread of a tumor located elsewhere in the body, such as the liver, breast, lung and kidney. Primary tumors are classified as “benign” or “malignant.” Both can be life-threatening.

A child’s body makes cells when they are needed for development or repair.  A tumor develops when normal or abnormal cells multiply when they are not needed.  The words “benign” and “malignant” are generally used to describe how normal or abnormal the cells are when viewed under a microscope.  Tumors with cells that are similar in appearance to normal cells are called “benign.”  Tumors with cells that appear very different than normal cells are called “malignant.” A number of factors are taken into consideration while classifying the tumor as 'benign' or 'malignant'. 

Prognosis
Prognosis is a prediction about the future course of the disease and the likelihood of recovery.  Prognosis is based upon many factors including the type of tumor, its location and grade, the length of time your child has exhibited symptoms, the speed of growth, and treatment options.  The age of the child and the extent to which the tumor has affected the child’s ability to function are also important factors.

Brain Tumors in Children
The most common types of brain tumors in children are astrocytoma, medulloblastoma and ependymoma, however below is a full listing of pediatric tumor types.

Malignant - Medulloblastoma, PNET, ATRT, Ependymoma, Choroid plexus carcinoma, Anaplastic astrocytoma, Glioblastoma

Benign - Pilocytic astrocytoma, craniopharyngioma, choroid plexus papilloma, ganglioglioma, neurofibroma

Treatment Options 
Treatment of brain and spine tumors in children is different than treating adults. Children’s brains and bodies are still developing, so there are different considerations and standards of care. For most children, treatment starts with surgery. Histopathological examination following surgery will help to classify and grade the tumor. 

Following surgery, additional treatment may be required.  Possible therapies include:

  • Chemotherapy
  • Conventional radiation therapy
  • Stereotactic radiosurgery
  • Interventions to address side effects of the tumor or the treatment
  • Rehabilitation to regain lost strength and skills
  • Ongoing follow-up care to detect recurrence of the tumor and manage late effects of treatment


Complications following treatment

Treatment of brain tumors, benign or malignant, may involve morbidity leading to distress in the family. Some of the complications of treatment include
  • Physical disabilities such as weakness of muscles and diminished coordination 
  • Learning disabilities including problems with memory, attention, comprehension and information processing
  • Behavioral changes and emotional issues
  • Hearing and vision problems 
  • Seizures and other neurological issues  
  • Hormonal problems including slowed growth, hypo- or hyperthyroidism, diabetes, early or late puberty, and infertility
  • Damage to internal organs and/or other body systems 
  • The possibility of developing secondary cancers in other parts of the body or a recurrence of a tumor in the brain
Timely diagnosis and treatment by a multidisciplinary team helps achieve the best possible outcomes in children with brain tumors. 

For queries please contact mumbaistrokecare@gmail.com

Thursday, February 9, 2017

'Stroke Facts' Questionnaire


Please fill out the following questionnaire to see if you know the basics of 'Stroke'


Click on the Link Below


Stroke Literacy Questionnaire

Wednesday, February 1, 2017

Preparing for Brain Tumor Surgery

Whenever someone in the family is diagnosed with a 'Brain Tumor', it causes a lot of apprehension in in the family. Surgery is usually the first step in treating most benign and many malignant tumors. It is often the preferred treatment when a tumor can be removed without unnecessary risk of neurological damage.

Surgery might be recommended to: 
• Remove as much tumor as possible
• Provide a tumor tissue sample for an accurate diagnosis and for genomic testing
• Remove at least part of the tumor to relieve pressure inside the skull (intracranial pressure), or to reduce the amount of tumor to be treated with radiation or chemotherapy
• Enable direct access for chemotherapy, radiation implants or genetic treatment of malignant tumors • Relieve seizures (due to a brain tumor) that are difficult to control with medications

“Radiosurgery” is a type of intense radiation delivered to a tumor. It may be used instead of, or in addition to, conventional surgery. Radiosurgery is not surgery in the conventional sense, as no opening is made in the skull. In certain cases, it may offer similar benefit and lower risk or discomfort than conventional surgery.

Before surgery your doctor will consider the following: 

• Location of the tumor. Where the tumor is located will determine whether it is operable or inoperable.

• Diagnosis and size of tumor. If a tumor is benign, does not cause intracranial pressure (due to its small size) or cause problems with sensitive areas, avoiding or postponing surgery might be considered.

• Number of tumors. The presence of multiple tumors creates additional challenges to safe removal.

• The borders, or edges, of the tumor. If the tumor is poorly defined around the edges, it may be mixed with normal brain tissue and more difficult to remove completely.

• Your general health. Are your heart, lungs, liver and overall general health strong enough to endure the strains of surgery? If this is a metastatic brain tumor (one which began as a cancer elsewhere in your body), is the primary cancer controlled?

• Your neurological status. Do you have symptoms of increased intracranial pressure? Are there signs of nerve damage possibly caused by the tumor? If so, further evaluation may be needed before surgery is attempted.

• Previous surgery. If you’ve had recent surgery, it is usually necessary to recover from the previous procedure before going through another one.

• Other options. Is it likely that another treatment would provide equal or better results at comparable or lower risk? Your doctor will take these points into consideration in forming your treatment plan.

WHAT IS AN “OPERABLE TUMOR?” 

An operable tumor is typically one that your doctor believes can be surgically removed with minimal risk of brain damage.

WHAT IS AN “INOPERABLE TUMOR?” 

In some cases surgery may not be possible because the tumor is so deep within the brain that it is not accessible without excessive risk of brain damage. Tumors located in the brain stem and thalamus are two examples. Other tumors may present a problem if located near a sensitive area in the brain that controls language, movement, vision or other important functions. However, with advances in technology, the so called 'INOPERABLE TUMORS" can also not be safely resected with minimal damage to the surrounding brain.

Highly sensitive scans are used for this purpose and may include:
 • Computerized Tomography (CT)
• Magnetic Resonance Imaging (MRI)
• Magnetic Resonance Spectroscopy (MRS)
• Positron Emission Tomography (PET)

Diffusion Tensor Imaging MRI’s may be used to generate maps of the nerve pathways called “fiber tracking.” Use of fiber tracking may help the surgeon avoid disrupting important nerve connections within the brain itself. Vital areas can also be defined by a procedure called brain mapping. At the beginning of the surgery, tiny electrodes are placed on the outer layer of the brain. Stimulating these electrodes helps the neurosurgeon determine the functions of those sensitive parts of the brain so they can be avoided during surgery.

WHAT TYPE OF SURGERY MIGHT BE RECOMMENDED?

CRANIOTOMY 
A craniotomy is the most common type of surgery to remove a brain tumor. “Crani” means skull and “otomy” means cutting into. The procedure typically involves shaving a portion of the head, making an incision in the scalp, then using specialized medical tools to remove a portion of the skull. This enables the neurosurgeon to find the tumor and remove as much as possible. After the tumor is removed, the portion of skull that was cut out is replaced, and the scalp is stitched closed. Remember, all of this is done with drugs that relax you or put you to sleep. They also numb the scalp and other tissues. The brain itself does Sample of a head frame used during stereotactic biopsy Electra, LSS frame not “feel” pain, so brain surgery can be done with you awake if the surgeon believes it is necessary to minimize the risk of the procedure.

CRANIECTOMY 
A craniectomy is similar to a craniotomy in all ways except one. While “otomy” means cutting into, “ectomy” means removal. In a craniectomy the bone removed for access to the brain is not replaced before closing the incision. The neurosurgeon may perform a craniectomy if he or she expects swelling to occur following surgery, or if the skull bone is not reusable. When the bone is reusable it can be replaced at a later date when it will not cause additional pressure. The skull piece is stored by the medical facility until a time when it might be reused. If a craniectomy is done, you will receive instructions from your health care team for protecting the soft spot created by the missing bone.

STEREOTACTIC BIOPSY
A Stereotactic biopsy. The same procedure as a needle biopsy but performed with a computer-assisted guidance system that aids in the location and diagnosis of the tumor.

TRANSPHENOIDAL SURGERY 
Transphenoidal surgery is an approach often used with pituitary adenomas and craniopharyngiomas. The term “trans” means through and “sphenoid” refers to the sphenoid bone located under the eyes and over the nose. The entry point for the neurosurgeon is through an incision made under the upper lip and over the teeth or directly through the nostril.

EMBOLIZATION 
If a tumor has a large number of blood vessels, surgery can be difficult due to the bleeding that could result. Embolization is a technique neurosurgeons use to stop the blood flow to the tumor prior to removing it. A diagnostic test, called an angiogram, is performed to determine if a significant amount of blood is going to the tumor. If so, the neurosurgeon or neuroradiologist can insert a small “plug” made of wire or glue-like material into the vessel. This stops the blood flowing to the tumor, but not to normal parts of the brain. Tumor removal usually follows within a few days. This technique might also be used with tumors that contain a high number of blood vessels – referred to as “vascular” or “well-vascularized” tumors. Meningiomas, meningeal hemangiopericytomas and glomus jugulare tumors are typically well-vascularized tumors.

WHAT ARE THE COMMON RISKS OF BRAIN TUMOR SURGERY? 
Brain tumor surgery poses both general and specific risks. The general risks apply to anyone going through surgery for any reason and are not limited to brain tumor surgery. These include:
• Infection
• Bleeding
• Blood clot formation (hematoma)
• Blood pressure instability
• Seizures
• Weakness
• Balance/coordination difficulties
• Memory or cognitive problems
• Spinal fluid leakage
• Meningitis (infection causing inflammation of membranes covering the brain and spinal cord)
• Brain swelling
• Stroke
• Hydrocephalus (excessive fluid in the brain)
• Coma
• Death

Risks specific to brain tumor surgery depend greatly on the particular location of the tumor. Particular areas of the brain control functions such as vision, hearing, smell, movement of the arms and legs, coordination, memory, language skills, and other vital functions. The process of operating on the brain always includes some risk that nerves or blood vessels serving these areas will be damaged. This could result in partial or complete loss of sensation, vision, movement, hearing or other functions. When a tumor is located deep within the brain it increases the risk and range of possible complications.

HOW LONG WILL IT TAKE FOR ME TO RECOVER FROM SURGERY? 
Any type of surgery is a trauma to your body. Some people will recover faster than others. While there is no “normal” recovery period that applies to all people, your recovery time will depend on:
• The procedure used to remove your brain tumor
• The part of your brain where the tumor was located
• The areas of your brain affected by the surgery
• Your age and overall general health

Ask your neurosurgeon what you can expect as a reasonable recovery time. This will help you set realistic goals for yourself in the weeks following surgery.

Please send your queries to mumbaistrokecare@gmail.com

Sunday, September 11, 2016

Apps for Stroke Survivors - Apps for Aphasia Part - 2

The first part of the article was published earlier at 

Apps for Stroke Survivors Part 1


Text-to-Speech Apps Apps -  

Verbally (Free)
- Has basic words programmed and the ability to speak a specific message based on typed in words. Verbally provides text to speech through its onscreen keyboard, word bank and phrase banks, though to customise these banks you need to upgrade for a price.


iSpeech
: (Free) Type in text and listen with the iSpeech App.


Speak It: ($1.99)
This app lets you enter text into your iPhone and then have the application say it back to you using a number of different voices. You can select between male and female American accents or rather posh sounding male and female British accents instead. You simply select the accent using a roller deck-style menu and then tap in what you want it to say in the box above it.lets you enter text into your iPhone and then have the application say it back to you using a number of different voices. You can select between male and female American and British accents. 


Predictable: ($159.99)
This is a text based Augmentative and Alternative Communication (AAC) app designed to give a voice to someone who is unable to use their own. The app is most useful for people who have good cognitive abilities but have lost the ability to speak due to a variety of reasons such as Motor Neurone Disease, ALS, Cerebral Palsy, a head injury or a stroke.


TalkPath News (Free)
Lingraphica’s TalkPath™ News is an online news source for individuals who need help reading, listening or comprehending daily news.


Assistive Express:
This is an affordable Augmentative Alternative Communication (AAC) Device, catered to people with difficulty in speech. Assistive Express is designed to be simple and efficient, allowing users to express their views and thoughts at the most express manner, with natural sounding voices.


Apart from the ones listed above, Speech Magnet and Voice Dream Recorder are other Apps that can help patients with aphasia